ResearchProjects

The Subthreshold Opioid Use Disorder Prevention (STOP) Trial is an innovative study of early intervention to prevent opioid use disorder.  STOP, a primary care-based collaborative care intervention attempted to reduce opioid use and overdose risk, and prevent progression to the more severe condition of opioid use disorder, in adult patients who have risky use of illicit or prescription opioids.  This national study, conducted within the NIDA Clinical Trials Network (CTN) in five primary care sites, tested the efficacy of STOP versus enhanced usual care.

Abstract

Rostam-Abadi Y, Liebschutz JM, Subramaniam G, Stone R, Appleton N, Mazel S, Alexander K, Brill SB, Case A, Gelberg L, Gordon AJ, Hong H, Incze MA, Kawasaki SS, Kim T, Kline M, Lovejoy TI, McCormack J, Zhang S, McNeely J (2025).
Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site “Subthreshold Opioid Use Disorder Prevention” (STOP) Trial
Journal of General Internal Medicine [Epub 2025 Jun 2]. doi: 10.1007/s11606-025-09613-4.

Liebschutz JM, Subramaniam GA, Stone R, Appleton N, Gelberg L, Lovejoy TI, Bunting AM, Cleland CM..., McNeely J (2023).
Subthreshold opioid use disorder prevention (STOP) trial: A cluster randomized clinical trial: Study design and methods
Addiction Science and Clinical Practice, 18 (1), 70. doi: 10.1186/s13722-023-00424-8. PMCID: PMC10657560.